About Rabeprazole + Domperidone 20 mg/30 mg Capsule
Rabeprazole + Domperidone 20 mg/30 mg Capsule contains Rabeprazole 20 mg + Domperidone 30 mg (SR). This medicine combines rabeprazole, which reduces stomach acid, with domperidone, which helps the stomach empty and reduces nausea. It is used to treat acid reflux (GERD) and heartburn when they come with nausea, bloating or a feeling of fullness. It is usually taken once a day before a meal, for the shortest time needed.
Uses of Rabeprazole + Domperidone 20 mg/30 mg Capsule
- Gastro-oesophageal reflux disease (GERD) with nausea or bloating
- Heartburn and acidity
- Peptic ulcer symptoms with fullness or nausea, as advised by the doctor
Benefits
In acid reflux and acidity
Rabeprazole lowers stomach acid, which eases heartburn and allows the food pipe and stomach lining to heal. Domperidone helps food move through the stomach, easing nausea, bloating and fullness.
Side effects
Most side effects are mild. Talk to your doctor if any of them bother you or do not go away.
Common
- Headache
- Dry mouth
- Diarrhoea
- Stomach pain
- Wind (flatulence)
- Dizziness
Get medical help if you notice
- Fast or irregular heartbeat, palpitations or fainting — stop and seek medical help straight away
- Unusual muscle movements or stiffness — contact your doctor
- Breast swelling, milk discharge or missed periods — contact your doctor
- Severe or watery diarrhoea that does not go away — contact your doctor
- Muscle cramps, shaking, fits or irregular heartbeat — may be signs of low magnesium with long-term use; contact your doctor
- Passing less urine, or blood in the urine — possible kidney inflammation; contact your doctor
- Rash, especially on sun-exposed skin, with joint pain — contact your doctor
- Allergic reaction: swelling of the face or throat, difficulty breathing — seek emergency care
How to use
Take it exactly as your doctor prescribed, usually once a day on an empty stomach about 30 minutes to an hour before a meal. Swallow the capsule whole with water; do not crush or chew it.
How it works
Rabeprazole is a proton pump inhibitor; it blocks the 'pumps' in the stomach lining that release acid. Domperidone blocks dopamine receptors in the gut and in the part of the brain that triggers vomiting, helping the stomach empty faster and reducing nausea.
Safety advice
Alcohol Caution
No important interaction is known, but alcohol can increase acid and irritate the stomach. It is best avoided.
Pregnancy Consult your doctor
Use only if your doctor advises it. Tell your doctor if you are pregnant or planning a pregnancy.
Breastfeeding Consult your doctor
Small amounts may pass into breast milk. Ask your doctor before using it.
Driving Caution
It can cause dizziness or drowsiness in some people. Do not drive if you feel affected.
Kidney Consult your doctor
Tell your doctor if you have kidney disease; the dose may need to be changed.
Liver Unsafe
Domperidone must not be used in moderate or severe liver disease. Tell your doctor about any liver problem.
If you miss a dose
If you miss a dose, take it when you remember, before food if possible. If it is nearly time for the next dose, skip the missed one. Do not take two doses together.
Quick tips
- Take it before a meal for best effect.
- Use it for the shortest time advised; domperidone is meant for short-term use.
- Tell your doctor if you have heart problems, a slow or irregular heartbeat, or low potassium or magnesium.
- Avoid large, spicy or fatty meals, and do not lie down soon after eating.
Substitutes
Same salts in the same strength from other makers. Only switch brands on your doctor's or pharmacist's advice; our pharmacist checks every order against the prescription.
Fact box
- Chemical class
- Benzimidazole (rabeprazole); benzimidazolone derivative (domperidone)
- Therapeutic class
- Gastrointestinal
- Action class
- Proton pump inhibitor + dopamine D2 receptor antagonist (prokinetic)
- Habit forming
- No
- Prescription
- Required
Interactions with other medicines
Tell your doctor and pharmacist about every medicine, vitamin and herbal product you take.
| Medicine | What can happen |
|---|---|
| Ketoconazole, itraconazole, erythromycin, clarithromycin and some HIV medicines | Raise domperidone levels and the risk of serious heart rhythm problems — should not be used together |
| Other medicines that affect heart rhythm | Higher risk of an irregular heartbeat |
| Atazanavir and nelfinavir | Rabeprazole reduces their absorption, making them less effective |
| Methotrexate (high dose) | Its levels may rise |
| Digoxin | Its levels may rise |
This page is general information to help you understand your medicine. It is not a substitute for advice from your doctor or pharmacist. Do not start, stop or change a medicine on your own.
Written by the Asthra Health Care team from the approved prescribing information (Rabeprazole and domperidone prescribing information (CDSCO-approved labelling); EMA review of domperidone cardiac risk, 2014; NICE BNF: domperidone; rabeprazole). Pharmacist review pending.